In the contemporary global business environment, the interaction between business performance and various social, technological, and health factors has intensified markedly. This study explores how mental health, specifically depression and anxiety, along with the socioeconomic impact of the COVID-19 pandemic and the increasing use of social networks, influence business performance. The research is conducted in the metropolitan area of Barranquilla, Colombia, where Twitter data from 2020 was analyzed to assess sentiment trends related to workplace well-being. The findings suggest that mental health conditions and social network usage play a crucial role in shaping organizational resilience in a post-pandemic business landscape. The results highlight that while social networks can enhance communication and market reach, they also reflect significant emotional distress among the workforce. These insights contribute to a better understanding of how companies in Barranquilla adapted to pandemic-induced disruptions and emphasize the need for organizations to implement strategies that support employee mental health while leveraging digital tools for business sustainability.